It presides over the presbytery of the main chapel that is located in the central nave occupying the most solemn section of the enclosure where the crossing of the principal naves of the cathedral occurs.
It is regarded as the largest of Christendom and one of the most spectacular polychrome wood structures of its time. It is work carried out in successive phases over almost a century, beginning with traces of the Flemish sculptor Pieter Dancart, who in 1482 got an altarpiece of almost 30 meters high by almost 20 of width, with four bodies of height plus a bank, in horizontal and seven streets. In 1497 appears another teacher in front of the work also of Flemish origin that took care of it until 1505. From this moment, is recorded the intervention of the sculptor Pedro Millán, who in turn, was replaced by Jorge Fernandez Alemán who helps his brother Alejo, taking care of both of the work until 1529, year in which it can be noted that concludes the first constructive phase of the altarpiece. A second phase began in 1550, when deciding on Cabildo to add two lateral streets forming a straight angle with the main front. In these works, Roque Balduque, Juan Bautista Vázquez and Pedro de Heredia participated, completing the whole in 1564.
The altarpiece has a set of forty-four reliefs and more than two hundred figures of saints that are arranged in the pilasters that articulate the altarpiece. On the wide, soaring canopy, set up by octagonal caissons, there is a beam in the centre of which a piety is flanked by an apostolate, by Jorge Fernandez; Crown the whole a monumental gothic calvary of the 14th century, preserved from before and decided to finish the entire altarpiece. The crucifix that chairs the Calvary traditionally receives the name of Christ of the million, for the million thanks granted to the people of Seville in times of epidemics. The reliefs of the Bank of the altarpiece are the ancients of the same and represent three scenes of martyrdoms of saints; There are also views of Seville and the cathedral. In its center, is a magnificent gothic sculpture of the Virgin of the headquarters. In the first body of the altarpiece appears from right to left, the embrace of St. Joachim and St. Anne, the Birth of the Virgin, the Annunciation, the birth of Christ, the slaughter of the innocent, the circumcision and the Adoration of the Kings.
The second body includes the presentation of the child in the temple, the Baptism of Christ, the resurrection of Lazarus, the Assumption of the Virgin, the entry of Christ in Jerusalem, the Sacred Supper and the prayer in the orchard. In the third body, the arrest of Christ, the scourging, the coronation of Thorns, the Resurrection, Ecce Homo, the path of Calvary and the plundering. In the fourth body, the burial of Christ, the Marys in the sepulchre, the Magdalene at the feet of the risen Christ, the Ascension, Descent of Christ to Limbo, the supper of Emaus and the coming of the Holy Spirit. On the sides of the altarpiece and from the bottom to the left are the representations of the creation of Eve, the flight to Egypt, Christ among the doctors, the Transfiguration and the Magdalena anointing the feet of Christ. On the right are the original sin, the final judgement, the multiplication of the loaves and the fish, the expulsion of the merchants from the temple and the conversion of St. Paul. In the pillars that frame the whole of the altarpiece are eight reliefs with representation of kings of Israel and Judah. With all this information we finished the review of the great altarpiece Major cathedral Seville.